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Search Results for " respiratory syncytial virus "

52

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38343	Quercetin pentaacetate Pentaacetylquercetin	RSV	Microbiology/Virology
	Quercetin pentaacetate (Pentaacetylquercetin) 具有多种生物活性，包括抗氧化、抗炎和抗癌特性。 Quercetin pentaacetate 与 RSV 相互作用并抑制病毒在细胞表面的粘附。
T12774	RSV-IN-1	RSV	Microbiology/Virology
	RSV-IN-1 是一种有效的人呼吸道合胞病毒的抑制剂，IC50为 0.11 μM。
T9197	Sisunatovir hydrochloride RV521 HCl,Sisunatovir HCl	RSV	Microbiology/Virology
	Sisunatovir hydrochloride (RV521 HCl) 是一种可口服的 RSV-F 蛋白抑制剂，在体外对一组 RSV-A 和 RSV-B 病毒的临床分离株表现出有效的疗效，对 RSV-A 和 RSV-B 分离株的IC50分别为 1.4 nM 和 1.0 nM。
TP2230	Fusion glycoprotein (92-106) [Human respiratory syncytial virus]	Others	Others
	Fusion glycoprotein (92-106) [Human respiratory syncytial virus] is a peptide with the sequence H2N-Glu-Leu-Gln-Leu-Leu-Met-Gln-Ser-Thr-Pro-Pro-Thr-Asn-Asn-Arg-OH, MW= 1741.96.
T4380	Ac-CoA Synthase Inhibitor1 ACSS2 inhibitor	RSV; Fatty Acid Synthase	Metabolism; Microbiology/Virology
	Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) 是一种可逆的醋酸盐依赖性乙酰辅酶 A 合成酶 2 抑制剂，IC50为 0.6 µM，可抑制呼吸道合胞病毒。
TQ0085	Presatovir GS-5806,普沙托韦	RSV	Microbiology/Virology
	Presatovir (GS-5806) 是一种新型的口服生物可利用的 RSV 融合抑制剂，平均 EC50值为 0.43 nM。
T7353	RSV604 (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea	RSV	Microbiology/Virology
	RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) 是一种呼吸道合胞病毒抑制剂，可与 RSV 核蛋白结合，靶向核衣壳蛋白的 Kd 值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性，EC50平均值为 0.8 μM。
T2621	Rostafuroxin PST 2238	ATPase; RSV	Membrane transporter/Ion channel; Microbiology/Virology
	Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物，是一种口服有效的 Na+,K+-ATPase 抑制剂，具有抗高血压和抗 RSV 活性，用于研究治疗原发性高血压的试验。
T0684	Ribavirin Tribavirin,ICN-1229,NSC-163039,利巴韦林,RTCA	Dehydrogenase; HCV Protease; DNA/RNA Synthesis; Antibiotic; AChR; RSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ribavirin (Tribavirin) 是一种合成的呋喃核苷类似物，具有抗丙型肝炎病毒和其他 RNA 病毒的活性。
T1024	Roflumilast 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217	PDE; RSV	Metabolism; Microbiology/Virology
	Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4)，具有抗炎和潜在的抗肿瘤活性，作用于PDE4A1，PDEA4，PDEB1和PDEB2，IC50分别为 0.7，0.9，0.7 和 0.2 nM。
T5539	GS-443902 瑞德西韦代谢物	Nucleoside Antimetabolite/Analog; HCV Protease; SARS-CoV; DNA/RNA Synthesis; RSV; Drug Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Remdesivir triphosphate 是一种有效的病毒 RNA 依赖的 RNA 聚合酶抑制剂，对RSVRdRp 和 HCVRdRp 的IC50分别为 1.1 µM 和 5 µM。它是 Remdesivir 的活性三磷酸代谢物。
T77132	Clesrovimab MK-1654	Others	Others
	Clesrovimab (MK1654) 是一种抗呼吸道合胞病毒蛋白 F 人单克隆抗体，可用于预防和治疗呼吸道合胞病毒感染。
T13401	Ziresovir AK0529,RO-0529	RSV	Microbiology/Virology
	Ziresovir (RO-0529) 是一种呼吸道合胞病毒融合蛋白 (RSV F) 抑制剂，抑制 RSV 活性，可用于研究合胞病毒感。
T29187	YM-53403
	YM-53403是具有抗病毒活性，可有效抑制属于A 亚群和B 亚组的RSV 毒株的复制，可用来治疗呼吸道合胞病毒感染。
T60016	VV116 GS-621763-d1,JT001	SARS-CoV; RSV	Microbiology/Virology
	VV116 (JT001) 是一种针对呼吸道合胞病毒和 SARS-CoV-2 感染的选择性和口服活性核苷抗病毒剂。
T63253	AVG-233	DNA/RNA Synthesis; RSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	AVG-233 是一种可口服的RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，具有抗病毒活性，可阻断呼吸道合胞病毒和 SARS-CoV-2 复制。AVG-233 可用于研究呼吸道合胞病毒感染。
T26914	BTA-9881 BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564	RSV	Microbiology/Virology
	BTA-9881 是一种具有口服活性的新型 RSV 融合抑制剂，具有抗病毒活性，可用于研究呼吸道合胞病毒感染。
T26914L	(R)-AZD 9639	Others	Others
	(R)-AZD 9639 是 AZD 9639 的 R型异构体。AZD 9639 是一种新型呼吸道合胞病毒（RSV）融合抑制剂，具有抗病毒活性。
T15621	Rilematovir JNJ-53718678,JNJ-678	EGFR; RSV	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Rilematovir (JNJ-678) 是一种融合蛋白抑制剂，具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
T76907	Palivizumab Synagis,MEDI 493	RSV	Microbiology/Virology
	Palivizumab (MEDI 493) 是一种人源化 RSV 特异性单克隆抗体，选择性抑制RSV A和B亚型F蛋白A抗原位点的表位，可用于预防呼吸道合胞病毒感染 (RSV)。
T77100	Nirsevimab MEDI8897	RSV	Microbiology/Virology
	Nirsevimab (MEDI8897) 是一种具有修饰 Fc 区的重组人呼吸道合胞病毒 (RSV) 单克隆抗体。Nirsevimab 高效靶向 RSV-B ，Kd 值为 1.5 nM。Nirsevimab 可用于预防 RSV 感染。
T17107	TMC353121	Others	Others
	TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).
T26848	BMS-433771 free base BMS-433771,BMS 433771,BMS433771
	BMS-433771, a novel inhibitor of respiratory syncytial virus (RSV), binds the RSV F glycoprotein and inhibits membrane fusion.
T27271	Enzaplatovir BTA-585,BTA 585,BTAC585,BTA585,BTA-C585
	Enzaplatovir is an inhibitor of Respiratory Syncytial Virus (RSV), can be used as a viral fusion protein inhibitor.
T70502	AZ-27
	AZ-27 is a respiratory syncytial virus inhibitor which differentially inhibits different polymerase activities at the promoter.
T12775	RSV604 (R enantiomer) RSV604 R enantiomer	Others	Others
	RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is a respiratory syncytial virus (RSV) replication inhibitor.
T73268	hRSV-IN-1
	hRSV-IN-1 是一种呼吸道合胞病毒 (hRSV) 抑制剂。
T13046	Syncytial Virus Inhibitor-1	Others	Others
	Syncytial Virus Inhibitor-1 is a potent and orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion(EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively).
T14195	ALS-8112	Others	Others
	ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).
T36440	GS-441524 tris-isobutyryl ester
	GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50value of 0.26 μM. 1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey mode...
T70451	Blancoxanthone
	Blancoxanthone is a molecule isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS-CoV).
T16439	PC786	Others	Others
	PC786 shows effective antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM). PC786 is an inhaled respiratory syncytial virus L protein polymerase inhibitor.
T68826	A33903
	A33903 is a 1,4-benzodiazepine analog that is being studied as a potential inhibitor of respiratory syncytial virus. This molecule was moderately active and demonstrated good pharmacokinetic properties.
T77005	Felvizumab
	Felvizumab (SB 209763) 是一种人源化 IgG1κ 单克隆抗体，靶向RSVF 糖蛋白上的不同中和表位。
T61856	Antiviral agent 10
	Antiviral agent 10 是一种可抑制呼吸道合胞病毒 (RSV) 的抗病毒剂。
T35177	Xibornol Bactacine,Nanbacine	Antiviral; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T61704	RSV-IN-6
	RSV-IN-6 (Compound 53) is a specific agent that effectively inhibits the respiratory syncytial virus (RSV) by targeting the M2-1 protein. It shows strong potency, with EC50 values of 4.4 μM and 1.3 μM against RSV-A and RSV-B strains, respectively [1].
T61217	RSV-IN-3
	RSV-IN-3 (Compound 1) 是呼吸道合胞病毒 (RSV) 和流感病毒 A (IAV) 的双重抑制剂。RSV-IN-3 具有抗 RSV 活性 (EC50=32.70 μM)。
T72753	RSV604 racemate A-60444 racemate
	RSV604 (A-60444) racemate 是一种外消旋混合物，与 S-异构体相比，RSV604 racemate 对呼吸道合胞病毒(RSV)菌株的作用效果弱很多。
T40114	RSV-IN-2
	RSV-IN-2 is a powerful compound that acts as a dual inhibitor of both wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. It efficiently inhibits the activity of these proteins, with an EC50 value of 0.27 nM for the wild-type and 0.70 nM for the D486N-mutant protein.
T76752	Motavizumab
	Motavizumab (MEDI-524)为针对humanRSV(呼吸道合胞病毒)的单克隆抗体。该化合物主要应用于对高危婴儿的呼吸道合胞病毒感染的研究。
T27668	JNJ-2408068 R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500
	JNJ-2408068 is an inhibitor of respiratory syncytial virus (RSV). JNJ-2408068 exhibited potent antiviral activity with EC50 of 2.1 nM. A similar inhibitory effect was observed in a RSV-mediated cell fusion assay (EC50= 0.9 nM). JNJ-2408068 interferes with
T60910	RSV-IN-4
	RSV-IN-4 (Compound 2) 具有抗 RSV 活性，EC50值为11.76 μM。RSV-IN-4 是呼吸道合胞病毒 (RSV) 和甲流病毒 A (IAV) 的双重抑制剂。
T72105	BMS-433771 dihydrochloride hydrate
	BMS-433771 dihydrochloride hydrate 是一种有效的呼吸道合胞病毒 (RSV) 抑制剂，具有口服活性。BMS-433771 dihydrochloride hydrate 对 A 组和 B 组RSV 均有效，EC50均值为 20 nM。BMS-433771 dihydrochloride hydrate 可用于呼吸道疾病的研究。
T69014	Sekikaic Acid
	Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM. Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml). It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).
T71291	EICAR
	EICAR is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. It is a nucleoside derivative which has both anti-cancer and antiviral effects, and was originally developed for the treatment of leukemia, but was unsuccessful in human clinical trials. It has broad spectrum antiviral effects with activity against vaccinia virus, Semliki forest virus, Junin virus, reovirus, influenza, measles virus and respiratory syncytial virus among others, although it is not active against SARS. T...
T63433	RSV-IN-5
	RSV-IN-5 是有效的野生型和突变呼吸道合胞病毒 (RSV) 融合蛋白的双重抑制剂。RSV-IN-5 能够作用于野生型 A2 F 蛋白及 D486N 突变 F 蛋白，他们的EC50值分别为2.0 nM、8.1 nM，表现出有效的抗 RSV 作用。
T62469	RSV/IAV-IN-3
	RSV/IAV-IN-3 (compound 14'i) 是一种双重的呼吸道合胞病毒 (RSV) (EC50: 2.92 μM) 和甲型流感病毒 (IAV) (EC50: 1.90 μM) 的双重抑制剂。RSV/IAV-IN-3 对 H1N1 和 H3N2 表现出抗病毒作用，在 MDCK 细胞中的 EC50值分别为 3.25 μM 和 1.50 μM。RSV/IAV-IN-3 能够剂量依赖性地明显抑制荧光素酶的活性 (EC50: 3.89 μM)。RSV/IAV-IN-3 可以抑制 IAV 感染和 RdRp 活性，在进入后阶段抑制 IAV 和 RSV 复制。
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

化合物

Quercetin pentaacetate

Cat.No: T38343

Synonym: Pentaacetylquercetin

Target: RSV

Cat.No: T12774

Target: RSV

Sisunatovir hydrochloride

Cat.No: T9197

Synonym: RV521 HCl,Sisunatovir HCl

Target: RSV

Fusion glycoprotein (92-106) [Human respiratory syncytial virus]

Cat.No: TP2230

Target: Others

Ac-CoA Synthase Inhibitor1

Cat.No: T4380

Synonym: ACSS2 inhibitor

Target: RSV, Fatty Acid Synthase

Cat.No: TQ0085

Synonym: GS-5806,普沙托韦

Target: RSV

Cat.No: T7353

Synonym: (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

Target: RSV

Cat.No: T2621

Synonym: PST 2238

Target: ATPase, RSV

Cat.No: T0684

Synonym: Tribavirin,ICN-1229,NSC-163039,利巴韦林,RTCA

Target: Dehydrogenase, HCV Protease, DNA/RNA Synthesis, Antibiotic, AChR, RSV

Cat.No: T1024

Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

Target: PDE, RSV

Cat.No: T5539

Synonym: 瑞德西韦代谢物

Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite

Cat.No: T77132

Synonym: MK-1654

Target: Others

Cat.No: T13401

Synonym: AK0529,RO-0529

Target: RSV

Cat.No: T29187

Cat.No: T60016

Synonym: GS-621763-d1,JT001

Target: SARS-CoV, RSV

Cat.No: T63253

Target: DNA/RNA Synthesis, RSV

Cat.No: T26914

Synonym: BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564

Target: RSV

Cat.No: T26914L

Target: Others

Cat.No: T15621

Synonym: JNJ-53718678,JNJ-678

Target: EGFR, RSV

Cat.No: T76907

Synonym: Synagis,MEDI 493

Target: RSV

Cat.No: T77100

Synonym: MEDI8897

Target: RSV

Cat.No: T17107

Target: Others

BMS-433771 free base

Cat.No: T26848

Synonym: BMS-433771,BMS 433771,BMS433771

Cat.No: T27271

Synonym: BTA-585,BTA 585,BTAC585,BTA585,BTA-C585

Cat.No: T70502

RSV604 (R enantiomer)

Cat.No: T12775

Synonym: RSV604 R enantiomer

Target: Others

Cat.No: T73268

Syncytial Virus Inhibitor-1

Cat.No: T13046

Target: Others

Cat.No: T14195

Target: Others

GS-441524 tris-isobutyryl ester

Cat.No: T36440

Cat.No: T70451

Cat.No: T16439

Target: Others

Cat.No: T68826

Cat.No: T77005

Antiviral agent 10

Cat.No: T61856

Cat.No: T35177

Synonym: Bactacine,Nanbacine

Target: Antiviral, Antibiotic

Cat.No: T71856

Cat.No: T61704

Cat.No: T61217

RSV604 racemate

Cat.No: T72753

Synonym: A-60444 racemate

Cat.No: T40114

Cat.No: T76752

Cat.No: T27668

Synonym: R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500

Cat.No: T60910

BMS-433771 dihydrochloride hydrate

Cat.No: T72105

Cat.No: T69014

Cat.No: T71291

Cat.No: T63433

Cat.No: T62469

Cat.No: T38297

Synonym: Ribavirin-13C5

Cat. No.	Product Name	Target	Signaling Pathways
T3417	Amentoflavone Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin	Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal	Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物，有抗炎、抗氧化和神经保护等作用。
TN3048	4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	RSV	Microbiology/Virology
	4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) 是 Agastache rugosa 的一种活性成分。4-Methoxycinnamaldehyde 对人喉癌细胞系中的呼吸道合胞病毒 (RSV) 具有细胞保护活性，有助于控制 RSV 感染诱发的疾病，IC50 约为 0.055 μg/mL。

天然产物

Cat.No: T3417

Synonym: Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin

Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal

4-Methoxycinnamaldehyde

Cat.No: TN3048

Synonym: p-Methoxycinnamaldehyde

Target: RSV

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